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The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer
(2017)
Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many ...
Prolactin gene expression in the pituitary of rats subjected to vaginocervical stimulation requires Erk-1/2 signaling
(Institute animal reproduction food research, 2017)
Vaginocervical stimulation (VCS) induces twice-daily prolactin (PRL) surges resulting in pseudopregnancy in the rat. Furthermore, activation of the extracellular signal-regulated kinase-1/2 (Erk-1/2) is involved in the ...
ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
(Frontiers Media S.A., 2018-10)
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we ...
Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding
(American Chemical Society, 2016-03)
The mitogen-activated protein kinase ERK2 is able to elicit a wide range of context-specific responses to distinct stimuli, but the mechanisms underlying this versatility remain in question. Some cellular functions of ERK2 ...
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
(Society of Biology of Chile, 2002)
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
(Sociedad de Biología de Chile, 2006)
Subcellular distribution of ERK phosphorylation in tyrosine and threonine depends on redox status in murine lung cells
(Public Library of Science, 2018-02)
Activation of ERK1/2 implies the phosphorylation of tyrosine (pTyr) and threonine (pThr) by MEK1/2; both reactions were thought to be cytoplasmic, promoting ERK to reach the nucleus where it activates several transcription ...
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
(Sociedad de Biología de Chile, 2002)
Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus
(Elsevier Ireland, 2015-08)
Melanocortins are neuropeptides with well recognized anti-inflammatory and anti-apoptotic effects in the brain. Of the five melanocortin receptors (MCR), MC4R is abundantly expressed in the brain and is the only MCR present ...
Activation of ERK2 in basolateral amygdala underlies the promoting influence of stress on fear memory and anxiety: Influence of midazolam pretreatment
(Elsevier Science, 2013-10)
Exposure to emotionally arousing experiences elicits a robust and persistent memory and enhances anxiety. The amygdala complex plays a key role in stress-induced emotional processing and in the fear memory formation. It ...