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Benchmark datasets of immune receptor-epitope structural complexes
(BioMed Central, 2019-10)
Background: The development of accurate epitope prediction tools is important in facilitating disease diagnostics, treatment and vaccine development. The advent of new approaches making use of antibody and TCR sequence ...
Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes
(Elsevier, 2015)
Computational prediction of HLA class II restricted T cell epitopes has great significance in many immunological studies including vaccine discovery. In recent years, prediction of HLA class II binding has improved ...
Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts
(Springer, 2013)
The neuraminidase (NA) epitope from the Mexican AH1N1 influenza virus was identified by using sequences registered at the GenBank during the peak of a pandemic (from April 2009 to October 2010). First, NA protein sequences ...
Evaluation and Comparison of the Ability of Online Available Prediction Programs to Predict True Linear B-cell Epitopes
(Bentham Science Publishers, 2013-06)
This work deals with the use of predictors to identify useful B-cell linear epitopes to develop immunoassays. Experimental techniques to meet this goal are quite expensive and time consuming. Therefore, we tested 5 free, ...
BepiPred-2.0: Improving sequence-based B-cell epitope prediction using conformational epitopes
(Oxford University Press, 2017-07)
Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner. ...
The Immune Epitope Database and Analysis Resource Program 2003–2018: reflections and outlook
(Springer, 2019-11)
The Immune Epitope Database and Analysis Resource (IEDB) contains information related to antibodies and T cells across an expansive scope of research fields (infectious diseases, allergy, autoimmunity, and transplantation). ...
Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery
(Springer Heidelberg, 2014-12)
The binding of peptides to classical major histocompatibility complex (MHC) class I proteins is the single most selective step in antigen presentation. However, the peptide-binding specificity of cattle MHC (bovine leucocyte ...
Development of bióinformatics tools to analyse peptide-protein interactións: immunoinformatics applicatións in next generatión vaccine design
(2017)
Epitope-based vaccines (EVs) make use of short, antigen-derived peptides corresponding
to epitopes that are administered lo trigger a protective humoral (B-cell epitopes) and/or
cellular (T-cell epitopes) immune response. ...
QSPR-Perturbation Models for the Prediction of B-Epitopes from Immune Epitope Database: A Potentially Valuable Route for Predicting “In Silico” New Optimal Peptide Sequences and/or Boundary Conditions for Vaccine Development
(Springer, 2016-12)
In the present study, three different physicochemical molecular properties for peptides were calculated using the program MARCH-INSIDE: atomic polarizability, partition coefficient, and polarity. These measures were used ...