Now showing items 1-10 of 113
Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes
Computational prediction of HLA class II restricted T cell epitopes has great significance in many immunological studies including vaccine discovery. In recent years, prediction of HLA class II binding has improved ...
Evaluation and Comparison of the Ability of Online Available Prediction Programs to Predict True Linear B-cell Epitopes
(Bentham Science Publishers, 2013-06)
This work deals with the use of predictors to identify useful B-cell linear epitopes to develop immunoassays. Experimental techniques to meet this goal are quite expensive and time consuming. Therefore, we tested 5 free, ...
BepiPred-2.0: Improving sequence-based B-cell epitope prediction using conformational epitopes
(Oxford University Press, 2017-07)
Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner. ...
PTML Model for proteom Mining of B-cell Epitopes and Theoretic-Experimental Study of Bm86 Sequences from Colima Mexico
(Journal of Proteome Research, 2018)
Development of Bioinformatics Tools to Analyse Peptide-Protein Interactions: Immunoinformatics Applications in Next Generation Vaccine Design
Epitope-based vaccines (EVs) make use of short, antigen-derived peptides corresponding to epitopes that are administered lo trigger a protective humoral (B-cell epitopes) and/or cellular (T-cell epitopes) immune response. ...
QSPR-Perturbation Models for the Prediction of B-Epitopes from Immune Epitope Database: A Potentially Valuable Route for Predicting “In Silico” New Optimal Peptide Sequences and/or Boundary Conditions for Vaccine Development
In the present study, three different physicochemical molecular properties for peptides were calculated using the program MARCH-INSIDE: atomic polarizability, partition coefficient, and polarity. These measures were used ...
NetTepi: an integrated method for the prediction of T-cell epitopes
(Springer Verlag Berlín, 2014-08)
Multiple factors determine the ability of a peptide to elicit a cytotoxic T cell lymphocyte response. Binding to a major histocompatibility complex class I (MHC-I) molecule is one of the most essential factors, as no peptide ...
Induction of neutralizing antibodies against mutalysin-II from Lachesis muta muta Snake Venom Elicited by a conformational B-cell epitope predicted by Blue Star Sting data base.
(Immunome Research, v. 11, n. 1, Mar. 2015., 2015)
A comparative in silico linear B-cell epitope prediction and characterization for South American and African Trypanosoma vivax strains
Trypanosoma vivax is a parasite widespread across Africa and South America. Immunological methods using recombinant antigens have been developed aiming at specific and sensitive detection of infections caused by T. vivax. ...
MuPeXI: prediction of neo-epitopes from tumor sequencing data
Personalization of immunotherapies such as cancer vaccines and adoptive T cell therapy depends on identification of patient-specific neo-epitopes that can be specifically targeted. MuPeXI, the mutant peptide extractor and ...