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Epigenetic mechanisms and memory strength: A comparative study
(Elsevier, 2014-06)
Memory consolidation requires de novo mRNA and protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors regulate gene expression by ...
Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer’s Disease
(MDPI, 2022-10)
Healthy brain functioning in mammals requires a continuous fine-tuning of gene expression. Accumulating evidence over the last three decades demonstrates that epigenetic mechanisms and dynamic changes in chromatin organization ...
The prima donna of epigenetics: the regulation of gene expression by DNA methylation
(Associação Brasileira de Divulgação Científica, 2005)
Epigenetic mechanisms related to cognitive decline during aging
(Veterinary and Human Toxicology, 2019-05)
Cognitive decline is a hallmark of the aging nervous system, characterized by increasing memory loss and a deterioration of mental capacity, which in turn creates a favorable context for the development of neurodegenerative ...
Rapid dehydration induces long-term water deficit memory in sorghum seedlings: advantages and consequences
(2020-12-01)
Studies on water deficit follow methodologies with short recovery intervals, which makes it difficult to determine whether a long-lasting memory is imprinted. There is a paucity of information on the dehydration level and ...
Environmentally induced phenotypic plasticity and DNA methylation changes in a wild potato growing in two contrasting Andean experimental gardens
(Nature Publishing Group, 2021-01)
DNA methylation can be environmentally modulated and plays a role in phenotypic plasticity. To understand the role of environmentally induced epigenetic variation and its dynamics in natural populations and ecosystems, it ...
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
(2017)
Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
(2017)
Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...
Nrf2 pre‐recruitment at Enhancer 2 is a hallmark of H2O2‐induced epigenetic transcriptional memory in the HMOX1 gene in human umbilical artery endothelial cells
(2024)
Maternal obesity (MO) is a significant cause of increased cardiometabolic risk in offspring, who present endothelial dysfunction at birth. Alterations in physiologic and cellular redox status are strongly associated with ...