Buscar
Mostrando ítems 1-10 de 62
The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea
(Frontiers Media, 2021-10)
Vertebrate hair cell (HC) systems are innervated by efferent fibers that modulate their response to external stimuli. In mammals, the best studied efferent-HC synapse, the cholinergic medial olivocochlear (MOC) efferent ...
mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea
(Wiley Blackwell Publishing, Inc, 2017-06-01)
Key points: Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input ...
Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line
(Society for Neuroscience, 2020-11)
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons which aid to distinguish between external and self-generated stimuli, ...
Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus
(Society for Neuroscience, 2019-06)
The auditory system in many mammals is immature at birth but precisely organized in adults. Spontaneous activity in the inner ear plays a critical role in guiding this maturation process. This is shaped by an efferent ...
Efferent innervation and function
(Oxford University Press, 2012)
Mechanosensory hair cells of the organ of Corti and vestibular end organs transmit information regarding either sound or body position and motion to the central nervous system by way of peripheral afferent neurons. In ...
A gain-of-function mutation in the α9 nicotinic acetylcholine receptor alters medial olivocochlear efferent short-term synaptic plasticity
(Society for Neuroscience, 2018-04)
Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final ...
A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection
(Public Library of Science, 2009-01)
The transduction of sound in the auditory periphery, the cochlea, is inhibited by efferent cholinergic neurons projecting from the brainstem and synapsing directly on mechanosensory hair cells. One fundamental question in ...
Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells
(Society for Neuroscience, 2011-10)
In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically amplify the incoming sound waves by virtue ...
Difference in perseverative errors during a visual attention task with auditory distractors in alpha-9 nicotinic receptor subunit wild type and knock-out mice
(Frontiers Media S.A., 2017)
© 2017 Jorratt, Delano, Delgado, Dagnino-Subiabre and Terreros. The auditory efferent system is a neural network that originates in the auditory cortex and projects to the cochlear receptor through olivocochlear (OC) ...
The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?
(Pergamon-Elsevier Science Ltd, 2009-10)
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons. In return, the central nervous system provides feedback and modulates ...