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Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
(American Chemical Society, 2017)
© 2017 American Chemical Society. In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson's disease (PD) and, in spite of extensive research, no additional effective drugs have been discovered ...
DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells
(Springer, 2019)
Aminochrome has been reported to induce lysosomal dysfunction by inhibiting the vacuolar H-type ATPase localized inlysosome membrane. DT-diaphorase has been proposed to prevent aminochrome neurotoxicity but it is unknown ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome-induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
(Frontiers Research Foundation, 2014)
A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's ...
3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol
(Academic Press Inc., 2015)
© 2015 Elsevier Inc. Cholesterol plays an important role in inducing pancreatic β-cell dysfunction, characterized by an impaired insulin secretory response to glucose, representing a hallmark of the transition from ...
Dysfunctional chemosensation in myasthenia gravis : A systematic review
(2013-09)
Myasthenia gravis has traditionally been viewed as a disorder that solely affects the neuromuscular junction within the peripheral nervous system. However, there is now evidence that the cholinergic dysfunction of this ...
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: a New Target for Sepsis
(NLM (Medline), 2019)
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory ...