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Adjunctive effects of a sub-antimicrobial dose of doxycycline on clinical parameters and potential biomarkers of periodontal tissue catabolism
(MDPI Multidisciplinary Digital Publishing Institute, 2019)
Objectives: The aim of the present randomized, double-blind, placebo-controlled, parallel-arm study was to examine the effectiveness of a sub-antimicrobial dose of doxycycline (SDD) in combination with nonsurgical periodontal ...
Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition by doxycycline evokes synergistic lethality in breast cancer cells
(MDPI, 2020)
The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
Endoglin regulates cyclooxygenase-2 expression and activity
(LIPPINCOTT WILLIAMS & WILKINS, 2006-08-04)
The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of ...
Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells
(Springer Science+Business Media, 2014)
Divalent Metal Transporter 1 (DMT1) is
an apical Fe transporter in the duodenum and is
involved in endosomal Fe export. Four protein
isoforms have been described for DMT1, two from
mRNA with an iron responsive element ...
Antimicrobial susceptibility of strains of Propionibacterium acnes isolated from inflammatory acne
(2006)
In the last decade, a significant increase in the antimicrobial resistance of clinical specimens of Propionibacterium acnes to first line antibiotics used for acne treatment, has been informed in Europe and in the USA. No ...
Coxiella burnetii infection in a patient from a rural area of Monteria, Colombia
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Pública, 2014-11-01)
Q fever is a zoonosis caused by Coxiella burnetii. In Colombia, there have been very few human cases reported to date. This report describes the case of a 56-year-old patient with a background in agriculture and livestock ...
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi
(2012)
Background: Chagas' disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier. In the present study we analyzed the ...
A conditional tetracycline-regulated increase in gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat
(ENDOCRINE SOC, 2001-05)
Gamma amino butyric acid (GABA) is the main inhibitory neuro-transmitter controlling LH-releasing hormone (LHRH) secretion in the mammalian hypothalamus. Whether alterations in GABA homeostasis within discrete regions of ...
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines
(Elsevier, 2011-02)
Neutrophil collagenase or collagenase-2 (matrix metalloproteinase [MMP]-8) belongs to the collagenase
subgroup of the MMP superfamily of calcium- and zinc-dependent neutral proteinases. MMP-8 is catalytically
the most ...
Phenotypic and genotypic antimicrobial resistance in non-O157 Shiga toxin-producing Escherichia coli isolated from cattle and swine in Chile
(Frontiers Media, 2020)
Non-O157 Shiga toxin-producingEscherichia coli(STEC) is a zoonotic pathogen that causes bloody diarrhea and hemolytic-uremic syndrome in humans, and a major cause of foodborne disease. Despite antibiotic treatment of STEC ...