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Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment
(Blackwell Publishing, 2007-07-01)
Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated ...
Doxorubicin as an antioxidant: Maintenance of myocardial levels of lycopene under doxorubicin treatment
(Elsevier B.V., 2007-09-01)
The mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups ...
Exercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of rats
(Wiley-Blackwell, 2012-06-01)
The aim of this study was to investigate the effects of exercise in multiple organs of rats treated with doxorubicin. Male adult Wistar rats were distributed into the following groups: sedentary + NaCl; exercise + NaCl; ...
Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats
(Biomed Central Ltd., 2014)
Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy
(2018-02-01)
Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with ...
Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats
(Biomed Central Ltd., 2012-09-11)
Background: Doxorubicin is a potent chemotherapeutic drug used against a variety of cancers. It acts through interaction with polymerases and topoisomerase II and free radical production. Doxorubicin activity is not specific ...
Skeletal Muscle for Endomyocardial Biopsy: Comparable Stress Response in Doxorubicin Cardio-myopathy
(Journal Toxicology and Pathology, 2013)
Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
(Electrochemical Science Group, 2010-10-01)
The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and ...
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats
(2016-07-01)
Purpose We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods Sixteen rats were ...