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DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
(2021-04-15)
For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome ...
Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks
(2003)
The present report deals with the functional relationships among protein complexes which, when mutated, are responsible for four human syndromes displaying cancer proneness, and whose cells are deficient in DNA double-strand ...
Subtelomeric I-scei-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Research Foundation, 2016)
Subtelomeric I-scel-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Media SALausanne, 2016)
Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
(2020)
Hereditary mutations in polynucleotide kinasephosphatase
(PNKP) result in a spectrum of neurological
pathologies ranging from neurodevelopmental
dysfunction in microcephaly with early onset
seizures (MCSZ) to ...
Epigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis
(BAISHIDENG PUBLISHING GROUP INCPLEASANTON, 2015)
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii
(Frontiers in Bioscience, 2016-05)
Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...
Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells
(Elsevier Science, 2008-11)
Fludarabine (FLU), an analogue of adenosine, interferes with DNA synthesis and inhibits the chain elongation leading to replication arrest and DNA double strand break (DSB) formation. Mammalian cells use two main pathways ...
Current understanding of RAD52 functions: Fundamental and therapeutic insights
(Molecular Diversity Preservation International, 2020-03)
In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories ...