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Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor
(Springer Verlag, 2017)
© 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
(Frontiers Media, 2020)
The strength of goal-oriented behaviors is regulated by midbrain dopamine neurons. Dysfunctions of dopaminergic circuits are observed in drug addiction and obsessive-compulsive disorder. Compulsive behavior is a feature ...
Enhancement of blood pressure response to dopamine by Angiotensin II
(1981)
The interaction of dopamine and angiotensln II (AH) on blood pressure and heart rate was studied in rats. The influence of reserpine pretreatment and ragotomy was also studied. Inbred rats anesthetized with urethane received ...
Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour
(2002)
Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
Effect of dopamine on human gastric and pancreatic secretion
(1979)
It has previously been shown that dopamine stimulates pancreatic exocine secretion and inhibits acid secretion in the dog. In this study, the authors have investigated the effect of dopamine on human gastric and pancreatic ...
Theoretical study of dopamine. Application of the HSAB principle to the study of drug-receptor interactions
(Elsevier, 2000)
We present a theoretical conformational study of neutral and N- protonated form of dopamine in which we relate its pharmacological activity to the chemical hardness. We have found that the neutral form presents small ...
Salsolinol and isosalsolinol: Condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine
(2012)
Dopamine (DA) condenses, at least in vitro, with acetaldehyde, the primary metabolite of ethanol, to form the regioisomers salsolinol (SAL) and isosalsolinol (isoSAL). An alternative in vivo route to SAL, requiring a ...
Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways
(Elsevier, 2019)
Triadimefon (TDF) is a triazole fungicide extensively used in agriculture that has been found as a pollutant in numerous water sources. In mammals, it inhibits monoamine uptake through binding to the dopamine transporter, ...
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
(Elsevier, 2017)
There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons.
Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the
dopamine neurons of the substantia ...
Dopamine-dependent iron toxicity in cells derived from rat hypothalamus
(AMER CHEMICAL SOC, 2005-03)
We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...