Now showing items 1-10 of 1734
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...
A Protein–DNA Binding Mechanism Proceeds Through Multi-state or Two-state Parallel Pathways
The DNA-binding mechanism of the dimeric C-terminal domain of the papillomavirus E2 protein with its specific DNA target was investigated and shown to proceed through two parallel pathways. A sequential multi-step reaction ...
A phage display combined with DNA affinity magnetic system can be applied to a screening of DNA binding proteins, such as transcription factors
(Pontificia Universidad Católica de Valparaíso, 2010)
Water regulation of actinomycin-D binding to DNA: the interplay among drug affinity, DNA long-range conformation, and hydration
Actiaomycin-D (actD) binds to natural DNA at two different classes of binding sites, weak and strong. The affinity for these sites is highly dependent on DNA se(sequence and solution conditions, and the interaction appears ...
Whydration effects on DNA double helix stability modulates ligand binding to natural DNA in response to changes in water activity
(Cellular & Molecular Biology, 2001-07-01)
In this work we present evidence that water molecules are actively involved on the control of binding affinity and binding site discrimination of a drug to natural DNA. In a previous study, the effect of water activity ...
DNA binding, topoisomerase inhibition and cytotoxicity of palladium(II) complexes with 1,10-phenanthroline and thioureas
Metallointercalators represent a promising alternative in cancer chemotherapy. We present herein DNA binding, topoisomerase inhibition and cytotoxic studies on a series of complexes of general formulae [Pd(phen)(tu∗)2]2+ ...
Novel DNA-protein complex and a large DNA in SLE cryoprecipitates
(Clinical & Experimental Immunology, 2017)