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Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos
(Elsevier Inc, 2010-05-01)
Mouse oocytes acquire the ability to replicate DNA during meiotic maturation, presumably to ensure that DNA replication does not occur precociously between MI and MII and only after fertilization. Acquisition of DNA ...
Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices
(Oxford University Press, 2021-07)
Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated ...
Rad51 prevents Mre11-dependent degradation and excessive primpol-mediated elongation of nascent DNA after UV irradiation
(National Academy Of Sciences, 2015-12)
After UV irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication. However, it is unclear whether other mechanisms also facilitate the elongation of UV-damaged DNA. We wondered if ...
A new nonlinear DNA model
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2011)
The fork and the kinase: A DNA replication tale from a CHK1 perspective
(Elsevier Science, 2015-01)
Replication fork progression is being continuously hampered by exogenously introduced and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 (Chk1) is activated at replication forks that ...
Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
(Academic Press Ltd - Elsevier Science Ltd, 2017-09)
The cell cycle has gained attention as a key determinant for cell fate decisions, but the contribution of DNA replication and mitosis in stem cell differentiation has not been extensively studied. To understand if these ...
Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity
(Science Advances is the American Association for the Advancement of Science, 2020-12)
Chromosome instability (CIN) underpins cancer evolution and is associated with drug resistance and poor prognosis. Understanding the mechanistic basis of CIN is thus a priority. The structure-specific endonuclease Mus81-Eme1 ...
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing
(Nature Publishing Group, 2019-06)
The effectiveness of checkpoint kinase 1 (Chk1) inhibitors at killing cancer cells is considered to be fully dependent on their effect on DNA replication initiation. Chk1 inhibition boosts origin firing, presumably limiting ...
Yeast Srs2 helicase promotes redistribution of single-stranded DNA-Bound RPA and Rad52 in homologous recombination regulation
(Elsevier B.V., 2017-10)
Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly ...
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
(Nature, 2019-02)
DNA polymerase theta (Polθ), a member of the DNA polymerase family A, exhibits a polymerase C-terminal domain, a central domain, and an N-terminal helicase domain. Polθ plays important roles in DNA repair via its polymerase ...