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Iron overload induces changes of pancreatic and duodenal divalent metal transporter 1 and prohepcidin expression in mice
(Jena Gustav Fischer Verlag, 2014-06)
It is well known that the iron content of the body is tightly regulated. Iron excess induces adaptive changes that are differentially regulated in each tissue. The pancreas is particularly susceptible to iron-related ...
Regulatory mechanisms of intestinal iron absorption - uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis
(Wiley, 2010)
Knowledge on the intestinal iron transport process and the regulation of body iron stores has greatly increased during the last decade. The liver, through the sensing of circulating iron, is now recognized as the central ...
Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis
(Elsevier Science Inc., 2016)
Objective: To evaluate divalent metal transporter-1 (DMT1) expression in healthy women's and endometriosis patients' endometrium and to analyze DMT1 and ferritin light chain (Fn-L) expression modulation by iron overload ...
Hepcidin inhibits apical iron uptake in intestinal cells
(2007)
Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination
(Sociedad de Biología de Chile, 2006)
Increased hippocampal expression of the divalent metal transporter 1 (DMT1) mRNA variants 1B and +IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training.
(2010)
Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus ...
Iron, copper, and zinc transport: Inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA
(2012)
Iron (Fe), copper (Cu), and zinc (Zn) fulfill various essential biological functions and are vital for all living organisms. They play important roles in oxygen transport, cell growth and differentiation, neurotransmitter ...