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Amine-Derivatized l -Phenylalanine and l -Tyrosine as Versatile Self-Assembled Platforms of Diverse Supramolecular Architectures: From Mesocrystals to Organogels
(American Chemical Society, 2021-05-07)
Amino-acid-based systems have been specially investigated as potential functional biological or bioinspired materials. In this work, we show the remarkable ability of two small molecules based on the aryl amino acids ...
QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis
(Wiley, 2013-12)
Among 20 p450s of Mycobacterium tuberculosis (Mt), CYP121 has received an outstanding interest, not only due to its essentiality for bacterial viability but also because it catalyzes an unusual carbon-carbon coupling ...
Nickel(II) complexes based on L-amino-acid-derived ligands: Synthesis, characterization and study of the role of the supramolecular structure in carbon dioxide capture
(International Union of Crystallography, 2020-09)
The formation of the symmetrical 3-carbonate-bridged self-assembled trinuclear NiII complex Na2{[Ni(LO)2(H2O)]3(3-CO3)} (LO is the carboxylate anion of a l-tyrosine derivative), involves atmospheric CO2 uptake. The asymmetric ...
The role of thyroglobulin in thyroid hormonogenesis
(Springer, 2019-06)
In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. ...
Biochemical characterization and thermal inactivation of polyphenol oxidase from radish (Raphanus sativus var. sativus)
(Elsevier Science, 2013-04)
Polyphenoloxidase (PPO) is the target for the development of several food antibrowning agents. Different substrates (pyrocatechol, gallic acid, chlorogenic acid, caffeic acid, 3,4 dihydroxybenzoic acid, p-cumaric acid, ...
Characterization and expression analysis of KIT and MITF ‐M genes in llamas and their relation to white coat color
(Wiley Blackwell Publishing, Inc, 2019-02)
The llama (Lama glama) is a fiber-producing species that presents a wide range of coat colors, among which white is one of the most important for the textile industry. However, there is little information about the molecular ...
Identification of llama KRTAP7-1 and KRTAP8-1 fiber genes and polymorphism screening
(Elsevier Science, 2019-06)
Keratin-associated proteins (KAP)are one of the main structural components of hair fiber. Within this protein group, high glycine tyrosine (HGT)-KAP play a crucial role in the definition of their physical-mechanical ...
MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation
(Company of Biologists, 2019-07)
Mammalian spermatozoa must undergo biochemical and structural changes to acquire the capacity for fertilization, in a process known as capacitation. Activation of PKA enzymes is essential for capacitation, and thus cAMP ...
GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1
(American Physiological Society, 2020-04)
Lack of GABAB receptors in GABAB1 knockout mice decreases neonatal ARC kisspeptin 1 (Kiss1) expression in the arcuate nucleus of the hypothalamus (ARC) in females, which show impaired reproduction as adults. Our aim was ...
Low molecular weight amino acid-based derivatives: from organogels to single crystals and mesocrystals
(International Union of Crystallography, 2017-12)
Amino acids are able to self-assemble into ordered superstructures, also called mesocrystals, when they are subjected to certain crystallisation conditions such as, pH, supersaturation level and the use of additives, being ...