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Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance
(American Association for Cancer Research, 2011-11)
Concomitant tumor resistance (CR) is a phenomenon originally described in 1906 in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although recent studies have indicated ...
The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
(Elsevier Inc., 2017)
© 2017 Elsevier Inc. FtsZ (filamenting temperature-sensitive mutant Z) is a key protein in bacteria cell division. The wild-type Escherichia coli FtsZ sequence (FtsZwt) contains three tyrosine (Tyr, Y) and sixteen methionine ...
Purification and characterization of the active form of tyrosine hydroxylase from mesangial cells in culture
(Wiley-Blackwell, 2002-01-01)
The capacity of mesangial cells (MC) to produce catecholamines (CAs) has been investigated in our laboratory. To study the CA cascade, it is necessary to examine some steps in their metabolic pathway. Tyrosine hydroxylase ...
Oxidation and nitration of ribonuclease and lysozyme by peroxynitrite and myeloperoxidase
(ELSEVIER SCIENCE INC, 2009)
In spite of the many studies on protein modifications by reactive species, knowledge about the products resulting from the oxidation of protein-aromatic residues, including protein-derived radicals and their stable products, ...
Free radicals derived from γ-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals
(Elsevier, 2020)
The enhanced green fluorescent protein (eGFP) is one of the most employed variants of fluorescent proteins.
Nonetheless little is known about the oxidative modifications that this protein can undergo in the cellular ...
Amine-Derivatized l -Phenylalanine and l -Tyrosine as Versatile Self-Assembled Platforms of Diverse Supramolecular Architectures: From Mesocrystals to Organogels
(American Chemical Society, 2021-05-07)
Amino-acid-based systems have been specially investigated as potential functional biological or bioinspired materials. In this work, we show the remarkable ability of two small molecules based on the aryl amino acids ...
Mesangial cells are able to produce catecholamines in vitro
(Wiley-Blackwell, 2003-05-01)
Mesangial cells(MC) participate in the control of the glomerular function due to their ability to synthesize hormones and induce cell contraction. Since MC can produce various kinds of hormones, the purpose of the present ...
QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis
(Wiley, 2013-12)
Among 20 p450s of Mycobacterium tuberculosis (Mt), CYP121 has received an outstanding interest, not only due to its essentiality for bacterial viability but also because it catalyzes an unusual carbon-carbon coupling ...