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The effect of opioid antagonists on synergism between dexketoprofen and tramadol
(2009)
The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofacial pain. The interaction between dexketoprofen and co-administered tramadol was studied using isobolographic analysis. ...
Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol
(2007)
The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic ...
Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen
(Taylor & Francis, 2017-11-10)
This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the ...
Adrenergic modulation of dexketoprofen antinociception in murine formalin orofacial pain
(2021)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in pain whose mechanism of action is the inhibition of cyclooxygenase enzymes (COXs), however, there are evidence of other mechanisms of action, such as the ...
Noradrenergic modulation of Dex-ketoprofen analgesia in preclinical orofacial pain
(2022)
Dexketoprofen (DEX) is the dextrorotatory enantiomer of S (+) configuration with a high antinociceptive activity of ketoprofen. The aim of this study was to evaluate the pharmacological interaction of DEX with the noradrenergic ...
Nitric Oxide Mediated Dexketoprofen Antinociception
(2020)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used in the treatment of pain by their analgesic, anti-inflammatory and antipyretic properties. NSAIDs act via inhibition of cyclooxygenase enzymes, COX-1, COX-2 and ...
Receptors involved in dexketoprofen analgesia in murine visceral pain
(2020)
Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be ...
Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice
(Elsevier, 2011)
Animal models are used to research the mechanisms of pain and tomimic human pain. The purpose of this study
was to determine the degree of interaction between dexketoprofen and dexibuprofen, by isobolographic analysis
using ...
Receptors involved in dexketoprofen analgesia in murine visceral pain
(Indian Academy of Sciences, 2020-07-02)
Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be ...
Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice
(2012)
Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction ...