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Ciliary neurotrophic factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
(Society of Biology of Chile, 2003)
The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of
neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, ...
Sympathetic denervation of an extremity as a presentation form of apical lung cancer Denervación simpática de una extremidad como forma de presentación en cáncer del vértice pulmonar.
(1995)
We report a 56 years old male patient presenting with a sympathetic denervation of the right upper limb due to an apical lung cancer. Vasomotor paralysis of the limb was objectively documented with a contact termography. ...
Catecholamine uptake, storage, and regulated release by ovarian granulosa cells
(ENDOCRINE SOC, 2008-10)
Catecholamines present in the mammalian ovary are involved in many normal aspects of ovarian functions, including initial follicle growth, steroidogenesis, and pathological states such as polycystic ovary syndrome. Sympathetic ...
Toxina botulínica y su importancia en el campo de la rehabilitación
(Hospital Clínico Universidad de Chile, 2010)
Botulinum toxin, the most potent biological toxin, has become a powerful therapeutic tool for a growing number of clinical applications. It produces temporary denervation manifested by paralysis of muscles treated. Also ...
Temperature-dependent double spikes in C-nociceptors of neuropathic pain patients
(OXFORD UNIV PRESS, 2005-09)
Five patients with small-fibre neuropathy characterized by temperature-dependent spontaneous pain, hyperalgesia/allodynia and signs of neurogenic inflammation were studied clinically and thermographically, and by ...
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
(CrossMark, 2014)
Parkinson disease (PD) is characterized by the selective loss of
dopaminergic neurons of the substantia nigra pars compacta
(SNpc). Although growing evidence indicates that endoplasmic reticulum
(ER) stress is a hallmark ...
Neurotoxins and neurotoxicity mechanisms. An overview
(Springer New York LLC, 2006)
Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for studies otherwise unattainable, 3) specifically ...
Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: Role of sympathetic innervation
(ENDOCRINE SOC, 2003-10-01)
Administration of estradiol valerate (EV) to adult rats leads to anovulation and cystic ovarian morphology. Sympathetic ovarian nerve denervation (SONX) overcomes this disruption. In this study, we determined whether EV ...
Fine-tuning ER stress signal transducers to treat amyotrophic lateral sclerosis
(Frontiers Media SA, 2017)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis. The mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, ...
Proteostasis disturbance in amyotrophic lateral sclerosis
(Oxford University Press, 2017)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motoneurons in the brain and spinal cord leading to paralysis and death. Although the etiology of ALS remains poorly understood, ...