Drug repurposing involves finding new therapeutic uses for existing drugs, including marketed, discontinued, shelved, and investigational drugs. The advantages of this strategy are many: reduced drug development timeline, ...

Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound ...

The recent outbreak of Coronavirus disease (COVID-19), first in Eastern Asia and then essentially across the world has been declared a pandemic by the WHO. COVID-19 is caused by a novel virus SARS-CoV2 (2019-nCoV), against ...

Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug ...

Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19. Drug repurposing has become a promising approach because of the opportunity ...

Introduction: The current COVID-19 pandemic has resulted in disastrous human and economic costs, mainly due to the absence of specific treatments to ameliorate the effects of this emerging viral disease. Complementary to ...

Drug repurposing (i.e., finding new therapeutic uses for already known drugs, including approved, abandoned, discontinued, and investigational drugs) is being extensively applied worldwide to expedite the development of ...

Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, ...

The importance of coronaviruses as human pathogen has been highlighted by the recent outbreak of SARS-CoV-2 leading to the search of suitable drugs to overcome respiratory infections caused by the virus. Due to the lack ...

Background:A novel corona virus-2 disease has spread to 213 countries and territories across the globe. The corona pandemic has claimed more than 548,934 deaths worldwide till the evening of 8 th of July 2020 and the ...