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Effects of ozone exposure on the oxidative capacity for drug biotransformation in Wistar rats
(Toxicology and Environmental Chemestry, 2008)
Liver microsomal biotransformation of nitro-aryl drugs: Mechanism for potential oxidative stress induction
(JOHN WILEY & SONS LTD, 2004-11)
Toxic effects of several nitro-aryl drugs are attributed to the nitro-reduction that may be suffered in vivo, a reaction that may be catalysed by different reductases. One of these enzymes is NADPH-cytochrome P450 reductase, ...
Drug Metabolism
(Springer Nature Switzerland AG, 2018)
Through evolution, the body has developed different strategies to dispose metabolic 4waste and protect itself from exposure to potential toxic chemicals. It is useful to differentiate chemical compounds with a well-defined ...
CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
(Soc Brasileira Quimica, 2022-02-21)
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, ...
Chiral HPLC analysis of venlafaxine metabolites in rat liver microsomal preparations after LPME extraction and application to an in vitro biotransformation study
(SPRINGER HEIDELBERG, 2010)
A three-phase LPME (liquid-phase microextraction) method for the enantioselective analysis of venlafaxine (VF) metabolites (O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in microsomal preparations is described ...
Hormonal Regulation of Hepatic Drug Biotransformation and Transport Systems
(Wiley, 2013-10)
The human body is constantly exposed to many xenobiotics including environmental pollutants, food additives, therapeutic drugs, etc. The liver is considered the primary site for drug metabolism and elimination pathways, ...
Drug Metabolism Synthetic (Phase II) Reactions
(Springer Nature Switzerland AG, 2021)
In synthetic (or Phase II or conjugation) reactions, an endogenous or exogenous compound (the substrate of the reaction) is coupled to an endogenous conjugating moiety (sometimes called endocon). The conjugating moiety is ...
Solid phase microextraction and LC-MS/MS for the determination of paliperidone after stereoselective fungal biotransformation of risperidone
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
The present work describes for the first time the use of SPME coupled to LC-MS/MS employing the polar organic mode in a stereoselective fungal biotransformation study to investigate the fungi ability to biotransform the ...