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DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
(2021-04-15)
For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome ...
The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.
(2013-04-01)
We have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins ...
Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks
(2003)
The present report deals with the functional relationships among protein complexes which, when mutated, are responsible for four human syndromes displaying cancer proneness, and whose cells are deficient in DNA double-strand ...
Subtelomeric I-scei-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Research Foundation, 2016)
Subtelomeric I-scel-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Media SALausanne, 2016)
Effect of caffeine on in vivo processing of alkylated bases in proliferating plant cells
(ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003)
DNA damage was induced by either 2 mM ethylmethanesulfonate or I Gy of gamma-irradiation in Allium cepa L. root meristems. The percentage of DNA that migrated towards the anode during microelectrophoresis after alkali ...
The invariance of the total direct DNA strand break yield
(Amer Assoc Physicists Medicine Amer Inst PhysicsMelvilleEUA, 2011)
What's the signification of nuclear vacuoles in human sperm?
(2008-07-01)
The aim of this study was to determine the extent of DNA fragmentation and the presence of single/denatured or double stranded of DNA in sperm with large nuclear vacuoles (LNV) selected by high-magnification. A total of ...
What's the signification of nuclear vacuoles in human sperm?
(2008-07-01)
The aim of this study was to determine the extent of DNA fragmentation and the presence of single/denatured or double stranded of DNA in sperm with large nuclear vacuoles (LNV) selected by high-magnification. A total of ...