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Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus
(2008-12-01)
Impaired DNA repair efficiency in systemic lupus erythematosus (SLE) patients has been reported in some studies, mainly regarding the repair of oxidative damage, but little is known about repair kinetics towards primarily ...
DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria
(2019)
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved ...
DNA damage and repair in leukocytes of melanoma patients exposed in vitro to cisplatin
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Resistance to chemotherapeutic drugs can be an obstacle to a successful treatment of cancer patients in part associated with individual response and differences in the DNA repair system. The Comet assay is an informative ...
DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects
(Begell House Inc, 2014-11)
The objective of the present work was to study the fine kinetics of DNA repair in xeroderma pigmentosum (XP) syndrome, a complex disorder linked to a deficiency in repair that increases cancer susceptibility. The repair ...
Homeostasis of DNA integrity
(2017-01-01)
Homeostasis comprises the tendency of an organism or cell to regulate their chemical processes that take place internally so as to maintain health, vital functions and stability, owing to the coordinated response of its ...
Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet oxygen
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Melanins have been associated with the development of melanoma and its resistance to photodynamic therapy (PDT). Singlet molecular oxygen (102), which is produced by ultraviolet A solar radiation and the PDT system, is ...
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients
(2017-04-01)
Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma ...
Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals
(Birkhauser Verlag Ag, 2017-05)
The genome integrity of all organisms is constantly threatened by replication errors and DNA damage arising from endogenous and exogenous sources. Such base pair anomalies must be accurately repaired to prevent mutagenesis ...