Now showing items 1-10 of 1635
Nuclear and kinetoplast DNA synthesis in Trypanosoma cruzi, autoradiographical study with DNA polymerase inhibitors
DNA synthesis in epimastigote forms of Trypanosoma cruzi was studied autoradiographically by incorporation of [3H]thymidine in the nuclear and kinetoplast DNA. Both DNA were heavily labelled. Three eukaryotic DNA polymerase ...
Influence of hormones on DNA synthesis of breast tumors in culture
(Martinus Nijhoff/Dr. W. Junk Publishers, 1986)
Tissue culture techniques have been developed for studying the influence of hormones on human breast tissues. The present study demonstrated that estrogen induced a highly significant increase in3H-thymidine incorporation ...
Toxic and genotoxic effects of trivalent and hexavalent chromium - A review
During the last years, the emission of heavy metals to the environment has increased, causing a severe negative impact to the ecosystems and seriously compromising human health due to their mutagenic potential. Tri- (III) ...
The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.
We have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins ...
The identification of translesion DNA synthesis regulators: inhibitors in the spotlight
Over the past half-century, we have become increasingly aware of the ubiquity ofDNA damage. Under the constant exposure to exogenous and endogenous genomic stress, cells must attempt to replicate damaged DNA. The encounter ...
Effect of benzo[a]pyrene on DNA synthesis and DNA polymerase activity of rat liver nuclei
When benzo[a]pyrene (B[a]P) was administered intraperitoneally to rats 48 hr before they were killed, the DNA-synthesizing capability of isolated rat liver nuclei was decreased as compared with control animals. B[a]P also ...
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...