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On the mechanisms of dissolution of montroydite [HgO(s)]: Dependence of the dissolution rate on pH, temperature, and stirring rate
(Academic Press Inc Elsevier Science, 2006-05)
The dissolution behavior of montroydite (HgO) has been studied using a fully automated system. Dissolution data under equilibrium conditions are in agreement with previously published data and indicate that HgO solubility ...
Intrinsic dissolution simulation of highly and poorly soluble drugs for BCS solubility classification
(Dissolution Technologies, Inc, 2017)
Intrinsic dissolution testing allows characterizing drug substances through its dissolution rate when exposed to a specified surface area in a specific dissolution media, This can be used to determine if a drug substance ...
A discriminating dissolution method for glimepiride polymorphs
(Wiley-Blackwell, 2012-02-01)
Glimepiride, an oral antidiabetic drug, is practically insoluble in water and exists in two polymorphic forms, I and II, of which form II has higher solubility in water. Because the dissolution rate of drugs can depend on ...
A discriminating dissolution method for glimepiride polymorphs
(Wiley-Blackwell, 2012-02-01)
Glimepiride, an oral antidiabetic drug, is practically insoluble in water and exists in two polymorphic forms, I and II, of which form II has higher solubility in water. Because the dissolution rate of drugs can depend on ...
Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release
(Dissolution Technologies, Inc, 2014-01)
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available ...
Solid dispersions containing Albendazole: Influence of dissolution media composition on in vitro drug release
(Dissolution Technologies, Inc, 2014-05)
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available ...
Development and validation of an intrinsic dissolution method for nimodipine polymorphs
(Versita, 2014-05-01)
The polymorphs of nimodipine, Modification I (Mod I), the metastable racemate, and Modification II (Mod II), the stable conglomerate, were evaluated by means of the intrinsic dissolution procedure. for this purpose, a hydro ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(2010-01-01)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Effect of pH, anions and cations on the dissolution kinetics of humic acid particles
(Elsevier Science, 2009-09)
The dissolution kinetics of solid humic acid (HA) particles under different conditions is reported and analyzed. The dissolution rate at pH 4 and 5 is very slow and several years may take to achieve equilibration. The rate ...