Now showing items 1-10 of 23
Anti-inflammatory drug design by molecular hybridization approach
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors
(Biophysical SocietyBethesdaEUA, 2005)
Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor
(Endocrine SocWashingtonEUA, 2014)
Identification of a new hormone-binding site on the surface of thyroid hormone receptor
(Endocrine SocietyChevy Chase, 2014-04)
Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear ...
Identification Of A New Hormone-binding Site On The Surface Of Thyroid Hormone Receptor
(Endocrine Society, 2014)