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Anti-inflammatory drug design by molecular hybridization approach

Universidade Estadual Paulista (Unesp) (2011)

The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the ...

Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective

Talevi, Alan (Frontiers Research Foundation, 2015-09)

Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...

Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors

Martinez, L; Sonoda, MT; Webb, P; Baxter, JD; Skaf, MS; Polikarpov, I (Biophysical SocietyBethesdaEUA, 2005)

Molecular Dynamics Simulations Reveal Multiple Pathways Of Ligand Dissociation From Thyroid Hormone Receptors.

Martínez, Leandro; Sonoda, Milton T; Webb, Paul; Baxter, John D; Skaf, Munir S; Polikarpov, Igor (2005)

Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor

Souza, PCT; Puhl, AC; Martinez, L; Aparicio, R; Nascimento, AS; Figueira, ACM; Nguyen, P; Webb, P; Skaf, MS; Polikarpov, I (Endocrine SocWashingtonEUA, 2014)

Identification Of A New Hormone-binding Site On The Surface Of Thyroid Hormone Receptor.

Souza, P C T; Puhl, A C; Martínez, L; Aparício, R; Nascimento, A S; Figueira, A C M; Nguyen, P; Webb, P; Skaf, M S; Polikarpov, I (2014)

Identification of a new hormone-binding site on the surface of thyroid hormone receptor

Souza, P. C. T.; Puhl, A. C.; Martínez, L.; Aparício, R.; Nascimento, Alessandro Silva; Figueira, A. C. M.; Nguyen, P.; Webb, P.; Skaf, M. S.; Polikarpov, Igor (Endocrine SocietyChevy Chase, 2014-04)

Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear ...

De la inmunovigilancia al escape tumoral: Historia de un enemigo con múltiples estrategias de resistencia y contra-ataqueFrom immune surveillance to tumor-immune escape: the story of an enemy with multiple strategies of resistance and counterattack

Scharovsky, O. Graciela; Matar, Pablo; Zacarías Fluck, Mariano; Rico, María José; Rabinovich, Gabriel A. (Sociedad Española de Inmunología, 2012)

Ligand Dissociation From Estrogen Receptor Is Mediated By Receptor Dimerization: Evidence From Molecular Dynamics Simulations

Sonoda M.T.; Martinez L.; Webb P.; Skaf M.S.; Polikarpov I. (, 2008)

Identification Of A New Hormone-binding Site On The Surface Of Thyroid Hormone Receptor

Souza P.C.T.; Puhl A.C.; Martinez L.; Aparicio R.; Nascimento A.S.; Figueira A.C.M.; Nguyen P.; Webb P.; Skaf M.S.; Polikarpov I. (Endocrine Society, 2014)