Now showing items 1-10 of 107
Anti-inflammatory drug design by molecular hybridization approach
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
B-lactoglobulin's conformational requirements for ligand binding at the calyx and the dimer interphase : a flexible docking study
(Public Library of Science, 2013)
Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors
(Biophysical SocietyBethesdaEUA, 2005)