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RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling
(MDPI, 2021)
DDX3 is a cellular ATP-dependent RNA helicase involved in different aspects of RNA metabolism ranging from transcription to translation and therefore, DDX3 participates in the regulation of key cellular processes including ...
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
(Wiley-Blackwell, 2015)
Asp-Glu-Ala-Asp (DEAD)-box polypeptide 3, or DDX3, belongs to the DEAD-box family of ATP-dependent RNA
helicases and is known to play different roles in RNA metabolism ranging from transcription to nuclear export, ...
Understanding the Role of the DEAD-Box Helicase DDX3 in Viral and Cellular Messenger RNA Metabolism
(2015)
DEAD-box polypeptide 3, o DDX3, pertenece a la familia de las proteínas DEAD-box, las cuales corresponden a helicasas de ARN dependientes de ATP. DDX3 ha sido involucrada en diferentes procesos del metabolismo de ARN desde ...
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
(Elsevier, 2016)
DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel
therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear ...
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
(2016)
DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a
potential target for novel therapies aimed to overcome viral resistance. Previous studies have
shown that DDX3 promotes nuclear ...
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis
(2007)
Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this condition. This study investigated ...
Identification of germ cell-specific VASA and IFITM3 proteins in human ovarian endometriosis
(BioMed Central, 2015-10)
Background: Endometriosis is a gynaecological disorder that affects 6-10 % of female population. It is characterized by the presence of endometrial tissue outside the uterus, most often in the pelvic peritoneum or ovaries. ...
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection
(Public Library of Science, 2018-07)
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which ...