Now showing items 1-10 of 26
Understanding the Role of the DEAD-Box Helicase DDX3 in Viral and Cellular Messenger RNA Metabolism
DEAD-box polypeptide 3, o DDX3, pertenece a la familia de las proteínas DEAD-box, las cuales corresponden a helicasas de ARN dependientes de ATP. DDX3 ha sido involucrada en diferentes procesos del metabolismo de ARN desde ...
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear ...
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis
Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this condition. This study investigated ...
The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
(Oxford University Press, 2013)
Here, we show a novel molecular mechanism promoted by the DEAD-box RNA helicase DDX3 for translation of the HIV-1 genomic RNA. This occurs through the adenosine triphosphate-dependent formation of a translation initiation ...
Prognostic Impact of MYCN, DDX1, TrkA, and TrkC Gene Transcripts Expression in Neuroblastoma
(WILEY PERIODICALS, INC, 2011)
Background. The aims of this study were to define the mRNA expression profiles of MYCN, DDX1, TrkA, and TrkC in biopsy tumor samples from 64 Brazilian patients with neuroblastomas of different risk stages and to correlate ...
A genomic aproach to the molecular basis of the effect of parity on ovarian cancer risk
Background: Ovarian cancer (OC) continues to be the top ranking deadliest gynecological cancer worldwide. Several epidemiologic studies have shown an inverse relationship between OC risk and parity. Compared to the ...