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QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis

Dumas, Victoria Gisel; Defelipe, Lucas Alfredo; Petruk, Ariel Alcides; Turjanski, Adrian; Marti, Marcelo Adrian (Wiley, 2013-12)

Among 20 p450s of Mycobacterium tuberculosis (Mt), CYP121 has received an outstanding interest, not only due to its essentiality for bacterial viability but also because it catalyzes an unusual carbon-carbon coupling ...

Food consumption, cytochrome P450 3A4 (CYP3A4) presystemic inhibitors, and bioavailability of saquinavir

Amariles Muñoz, Pedro (Sociedad Española de Farmacia Hospitalaria (SEFH)ElsevierPromoción y Prevención FarmacéuticaMadrid, España, 2021)

First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America

Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; Vivot, Walter Oscar; Szusz, Wanda; Córdoba, Susana Beatríz; García Effron, Guillermo (American Society for Microbiology, 2018-10)

One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the ...

Triazole-resistance in environmental aspergillus fumigatus in latin american and african countries

Unknown author (MDPI, 2021)

Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis in regions with >10% ...

Priority contaminants in rainbow trouts (Oncorhynchus mykiss) from the township of mutiscua, Norte de Santander, ColombiaContaminantes prioritarios en truchas arcoiris (oncorhynchus mykiss) del municipio de mutiscua, norte de santander, colombia

Quijano, Alfonso; Navia, Javier; Portilla, Maghdiel (Universidad de Córdoba, 2014)

Chronic acrolein exposure in wistar rats: the effects of guarana extractsExposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaraná

da Silva Bittencourt, Leonardo; Schnorr, Carlos Eduardo; Copetti Santos, Daniela; Rostirolla, Diana Carolina; Moresco, Karla; Ozório, Pedro; Rodrigues Mingori, Moara; Heinfarth, Luana; Gelain, Daniel; Moreira, José Cláudio Fonseca (Corporación Universidad de la Costa, 2020)