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Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats
(Faculdade De Odontologia De Bauru - USP, 2010)
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) ...
Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation
(Elsevier Science BvAmsterdamHolanda, 2001)
Cyclooxygenase-2 prostaglandins mediate anandamide-inhibitory action on nitric oxide synthase activity in the receptive rat uterus
(Elsevier Science, 2012-06)
Anandamide, an endocannabinoid, prostaglandins derived from cyclooxygenase-2 and nitric oxide synthesized by nitric oxide synthase (NOS), are relevant mediators of embryo implantation. We adopted a pharmacological approach ...
Effects of a selective cyclooxygenase-2 inhibitor on endometrial epithelial cells from patients with endometriosis
(Oxford University Press, 2008)
Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, also has anti-proliferative properties and pro-apoptotic effects on different in vivo and in vitro models, two actions that may be efficacious in therapy for ...
Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma
(Wiley, 2015)
BACKGROUND: Cyclooxygenase-2 (COX-2) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data ...
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues
(Elsevier, 2019)
Objectives: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic ...
The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial- mesenchymal transition
(Frontiers Media, 2021)
The tumor microenvironment (TME) corresponds to a complex and dynamic
interconnection between the extracellular matrix and malignant cells and their
surrounding stroma composed of immune and mesenchymal cells. The TME ...
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury
(BIRKHAUSER VERLAG AG, 2010)
This work explored the role of inhibition of cyclooxygenases (COXs) in modulating the inflammatory response triggered by acute kidney injury. C57Bl/6 mice were used. Animals were treated or not with indomethacin (IMT) prior ...