Search
Now showing items 1-10 of 63
Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A
(University of Chicago Press, 2018-06)
Cyclic adenosine monophosphate (cAMP) is critical in immune regulation, and its role in tuberculosis infection remains unclear. We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis ...
Role of nitric oxide/cyclic GMP and cyclic AMP in β3 adrenoceptor-chronotropic response
(Academic Press Ltd - Elsevier Science Ltd, 2006-04)
In this study we determine different signaling pathways involved in â3 adrenoceptor- (â3-AR) dependent frequency stimulation in isolated rodent atria. Promiscuous coupling between different G-proteins and â3-AR could ...
Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines
(Nature, 2020-09)
Previously we demonstrated that multidrug resistance-associated protein 4 transporter (MRP4) mediates cAMP efflux in bovine spermatozoa and that extracellular cAMP (ecAMP) triggers events associated to capacitation. Here, ...
Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide
(Associação Brasileira de Divulgação Científica, 2002-12)
Adenylyl cyclase (AC) isoforms catalyze the synthesis of 3′,5′-cyclic AMP from ATP. These isoforms are critically involved in the regulation of gene transcription, metabolism, and ion channel activity among others. Nitric ...
Methods to Investigate Signal Transduction Pathways in Trypanosoma cruzi: Cyclic Nucleotide Phosphodiesterases Assay Protocols
(Springer, 2020-03)
Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fact, ...
Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation
(Oxford University Press, 2014-01)
Sperm capacitation has been largely associated with an increase in cAMP, although its relevance in the underlying mechanisms of this maturation process remains elusive. Increasing evidence shows that the extrusion of cAMP ...
Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation
(Wiley Periodicals Inc., 2017-06)
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation. It is well established that HCO3 − is essential for capacitation ...
Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: Insight into potential mechanisms
(Wiley Blackwell Publishing, Inc, 2015-04)
Background and Objectives: Anagrelide represents a treatment option for essential thrombocythemia patients. It lowers platelet counts through inhibition of megakaryocyte maturation and polyploidization, although the basis ...
SOX9 and SF1 are involved in cyclic AMP-mediated upregulationof anti-Müllerian gene expression in the testicular prepubertal Sertoli cell line SMAT1
(American Physiological Society, 2011-09)
In Sertoli cells, anti-Müllerian hormone (AMH) expression is upregulated by FSH via cyclic AMP (cAMP), although no classical cAMP response elements exist in the AMH promoter. The response to cAMP involves NF-κB and AP2; ...
Genetic engineering of Lactococcus lactis co-producing antigen and the mucosal adjuvant 3' 5'- cyclic di Adenosine Monophosphate (c-di-AMP) as a design strategy to develop a mucosal vaccine prototype
(Frontiers Research Foundation, 2018-09)
Lactococcus lactis is a promising candidate for the development of mucosal vaccines. More than 20 years of experimental research supports this immunization approach. In addition, 3' 5'- cyclic di-adenosine monophosphate ...