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Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut
(Public Library of Science, 2016)
Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion
(Public Library of Science, 2016)
Induction of autophagy increases the proteolytic activity of reservosomes during Trypanosoma cruzi metacyclogenesis
(Landes Bioscience, 2020-02)
Cruzipain, the major cysteine protease of the pathogenic protozoa Trypanosoma cruzi, is an important virulence factor that plays a key role in the parasite nutrition, differentiation and host cell infection. Cruzipain is ...
Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes
(Nature Publishing Group, 2017-09)
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox ...
Cysteine peptidases from Phytomonas serpens: biochemical and immunological approaches
(Oxford University Press, 2019)
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi
(Blackwell Publishing Ltd, 2001-12-01)
The Trypanosoma cruzi cysteine protease cruzipain contains a 130-amino-acid C-terminal extension, in addition to the catalytic domain. Natural cruzipain is a complex of isoforms, because of the simultaneous expression of ...
Redirection of the immune response to the functional catalytic domain of cruzipain improves protective immunity against Trypanosoma cruzi infection
(Oxford University Press, 2010-12)
Despite the strong immune responses elicited after natural infection with Trypanosoma cruzi or vaccination against it, parasite survival suggests that these responses are insufficient or inherently inadequate. T. cruzi ...