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The importance of bioactivation in computer-guided drug repositioning: Why the parent drug is not always enough
(Bentham Science Publishers, 2016-08)
Although bioactivation is a well-documented process and the role of active metabolites in the drug discovery field has long been recognized, drug metabolites are usually ignored in virtual screening campaigns oriented to ...
Higher screen time is associated with overweight, poor dietary habits and physical inactivity in Brazilian adolescents, mainly among girls
(European Journal Of Sport Science, 2015-08-04)
To analyse the associations between high screen time and overweight, poor dietary habits and physical activity in adolescents according to sex. The study comprised 515 boys and 716 girls aged 14-17 years from Londrina, ...
A mechatronic system applied to wear particle analysis
(2008-12-01)
This paper describes the development of a mechatronic system for a predictive maintenance grounded on wear particle analysis. The reckoning of wear particles containing in lubricating industrial oils brings the image ...
High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses
(2013-02-01)
Dengue virus is a mosquito-borne flavivirus that has a large impact in global health. It is considered as one of the medically important arboviruses, and developing a preventive or therapeutic solution remains a top priority ...
Modern drug discovery technologies: opportunities and challenges in lead discovery
(Bentham ScienceBussum, 2011-12)
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have ...
The XyloPhone: toward democratizing access to high-quality macroscopic imaging for wood and other substrates
(Brill, 2020-11-01)
One rate-limiting factor in the fight against illegal logging is the lack of powerful, affordable, scalable wood identification tools for field screening. Computer vision wood identification using smartphones fitted with ...
Volume images vector display based on a diffractive screen
(Optical Soc JapanTokyoJapão, 1999)
In silico screening strategies for novel inhibitors of parasitic diseases
(Informa HealthcareLondon, 2011-05)
Introduction: Parasitic diseases are a major global problem causing long-term disability and death, with severe medical and psychological consequences around the world. Despite the prevalence of parasitic disease, the ...
Virtual screening and its integration with modern drug design technologies
(Bentham Science PublishingSharjah, 2008-01)
Drug discovery is a highly complex and costly process, which demands integrated efforts in several relevant aspects involving innovation, knowledge, information, technologies, expertise, R&D investments and management ...