Now showing items 1-10 of 702
The importance of bioactivation in computer-guided drug repositioning: Why the parent drug is not always enough
(Bentham Science Publishers, 2016-08)
Although bioactivation is a well-documented process and the role of active metabolites in the drug discovery field has long been recognized, drug metabolites are usually ignored in virtual screening campaigns oriented to ...
Higher screen time is associated with overweight, poor dietary habits and physical inactivity in Brazilian adolescents, mainly among girls
(European Journal Of Sport Science, 2015-08-04)
To analyse the associations between high screen time and overweight, poor dietary habits and physical activity in adolescents according to sex. The study comprised 515 boys and 716 girls aged 14-17 years from Londrina, ...
A mechatronic system applied to wear particle analysis
This paper describes the development of a mechatronic system for a predictive maintenance grounded on wear particle analysis. The reckoning of wear particles containing in lubricating industrial oils brings the image ...
Computational tool for in silico screening of biosurfactants in metagenomic libraries
(Bogotá - UniandesMaestría en Ingeniería QuímicaFacultad de IngenieríaDepartamento de Ingeniería Química, 2015)
High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses
Dengue virus is a mosquito-borne flavivirus that has a large impact in global health. It is considered as one of the medically important arboviruses, and developing a preventive or therapeutic solution remains a top priority ...
Modern drug discovery technologies: opportunities and challenges in lead discovery
(Bentham ScienceBussum, 2011-12)
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have ...
Literary Film Adaptation for Screen Production: the Analysis of Style Adaptation in the Film Naked Lunch from a Quantitative and Descriptive Perspective
(Univ. La Serena Departamento de Artes y Letras Facultad de Humanidades, 2015)
Multiple minima hypersurfaces procedures for biomimetic ligands screening
In this work the interaction of the pesticide carbaryl with two groups of biomimetic ligands, peptides and MIPs was screened by multiple minima hypersurfaces (MMH) procedures, through the AM1 semiempirical method. Data ...