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Modulators of complement activation: a patent review (2008 - 2013)
(Informa Healthcare, 2014-03)
Introduction: The architecture of the complement system has evolved during the last 600 – 700 million years to become an amazingly efficient and highly versatile alerting and cell killing device. Under physiological ...
Anticomplementary Activity of Horse IgG and F(ab’)2 Antivenoms
(2014)
Envenomation by poisonous animals is a neglected condition according to the World Health Organization (WHO). Antivenoms are included in the WHO Essential Medicines List. It has been assumed that immunoglobulin G (IgG) ...
Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012)
Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies
(2017)
Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable immunostimulatory properties when inoculated in mammals, such as the generation of high levels of antibodies, a strong cellular reaction, ...
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin
(Elsevier Ltd, 2014)
Trypanosoma cruzi, the agent of Chagas' disease, the sixth neglected tropical disease worldwide, infects 10-12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes are complement-resistant ...