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Experimental Studies 1st Part. Clinical Trial [Estudios experimentales 1ª parte. El ensayo clínico]
(Universidad de la Frontera, 2015)
Os critérios da indústria farmacêutica no direcionamento dos ensaios clínicos: o que aumentaria a participação do Brasil?
(2022)
Os ensaios clínicos representam uma ferramenta essencial de geração de conhecimento e inovação para a indústria farmacêutica. Apesar de o Brasil ser o 7º maior mercado para a indústria e apresentar uma demografia diversa ...
Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit
(Elsevier, 2017)
Objective: We explored how investigators of ongoing or planned trials respond to the publication of a trial stopped early for benefit addressing a similar question. Study Design and Setting: We searched multiple databases ...
Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum
(Oxford University Press, 2023)
Participants enrolled in cardiovascular disease (CVD) randomized controlled trials are not often representative of the population living with the disease. Older adults, children, women, Black, Indigenous and People of ...
Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
(BioMed Central, 2013)
Background: Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials ...
Monitoring in clinical trials of complementary and alternative medicine
Background
Clinical trial monitoring is an essential activity for quality assurance (QA) to ensure the protection of
human rights and the reliability and transparency of the data collection process. The purpose of ...
Botanical drug clinical trial: common issues and future options
Botanical drugs are plant-derived, complex mixtures which may have synergistic effects.
In order to understand this disparity between human use and drugs approved by regulatory agencies,
we analyzed botanical drug clinical ...
Twenty-two years’ experience registering trials in a low-middle income country: The Peruvian Clinical Trial Registry
(Blackwell Publishing Inc., 2019)
Aim: This study analyzes the quantitative and qualitative evolution of the Peruvian Clinical Trial Registry during the last 22 years. Methods: Following a cross-sectional design, we reviewed all clinical trials registered ...
Twenty-two years’ experience registering trials in a low-middle income country: The Peruvian Clinical Trial Registry
(Blackwell Publishing Inc., 2019)
Aim: This study analyzes the quantitative and qualitative evolution of the Peruvian Clinical Trial Registry during the last 22 years. Methods: Following a cross-sectional design, we reviewed all clinical trials registered ...
Brazilian Clinical Trials Registry and the challenges for clinical research governance
(Wiley-Blackwell, 2023)