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Bio-click chemistry: a bridge between biocatalysis and click chemistry
(2022)
The fields of click chemistry and biocatalysis have rapidly grown over the last two decades. The development of robust and active biocatalysts and the widespread use of straightforward click reactions led to significant ...
Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach
(SPRINGER, 2011)
The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new ...
Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols
(Royal Society of Chemistry, 2013-02)
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium ...
Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs.
(Elsevier Science Inc, 2014-01)
A series of 1,2,3-triazolylsterols was prepared from pregnenolone through reductive amination and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). The newly generated stereocenter of the key propargylamino ...
Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides
(Pergamon-Elsevier Science Ltd, 2009-03)
Readily prepared copper nanoparticles have been found to effectively catalyse the 1,3-dipolar cycloaddition of a variety of azides and alkynes furnishing the corresponding 1,2,3-triazoles in excellent yields. Both the ...
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
(Arkat USA, 2011-02)
A series of 4-[(triazolyl)methoxy]phenyl analogs of the phenoxyphenyl-substituted thiirane SB-3CT 1 was evaluated for its ability to inhibit gelatinases, members of the matrix metalloproteinase family of enzymes. The ...
Synthesis of 1,2,3-triazolylpyranosides through click chemistry reaction
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
We have developed an efficient method for the synthesis of functionalized C-glycosyl 1,2,3-triazoles through a Cu(1)-promoted azide-alkyne 1,3-dipolar cycloaddition between a TMS-protected C-alkynyl-glycoside and organic ...
Preparation of bifunctional mesoporous silica nanoparticles by orthogonal click reactions and their application in cooperative catalysis
(Wiley-VCH VerlagWeinheim, 2012-12)
The synthesis of bifunctional mesoporous silica nanoparticles is described. Two chemically orthogonal functionalities are incorporated into mesoporous silica by co-condensation of tetraethoxysilane with two orthogonally ...
Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry
(Molecular Diversity Preservation International, 2018-06)
Naturally occurring terpenes were combined by click reactions to generate sixteen hybrid molecules. The diterpene imbricatolic acid (IA) containing an azide group was used as starting compound for the synthesis of all the ...