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Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells
(Elsevier B.V., 2019)
© 2018The in vitro process of chondrogenic differentiation of mesenchymal stem cells (MSCs) induces a pre-apoptotic hypertrophic phenotype, guided by the active status of the WNT/β‑catenin pathway. To achieve a stable ...
High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis
Collagen synthesis is severely diminished in osteoarthritis; thus, enhancing it may help the regeneration of cartilage. This requires large amounts of glycine, proline and lysine. Previous works of our group have shown ...
An evaluation of chondrocyte morphology and gene expression on superhydrophilic vertically-aligned multi-walled carbon nanotube films
(Elsevier B.V., 2013-03-01)
Cartilage serves as a low-friction and wear-resistant articulating surface in diarthrodial joints and is also important during early stages of bone remodeling. Recently, regenerative cartilage research has focused on ...
Ectopic mineralization of articular cartilage in the bullfrog Rana catesbeiana and its possible involvement in bone closure
(Springer-verlagNew YorkEUA, 2002)
Regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression by interleukin-1 beta (IL-1 beta), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes
(Hospital Clinicas, Univ Sao PauloSao PauloBrasil, 2012)
Effects of zinc on structural characteristics of proteoglycans synthesized by proliferating and hypertrophic chondrocytes in culture
(1996)
Zinc (Zn) supplementation has been shown to stimulate longitudinal growth under marginal nutritional status. The mechanisms by which Zn stimulates longitudinal growth are still unknown. We have previously investigated the ...
L-type calcium channels in growth plate chondrocytes participate in endochondral ossification
(2007)
Longitudinal bone growth occurs by a process called endochondral ossification that includes chondrocyte proliferation, differentiation, and apoptosis. Recent studies have suggested a regulatory role for intracellular Ca-2 ...
Regulation of Chondrogenesis by Transforming Growth Factor-beta 3 and Insulin-like Growth Factor-1 from Human Mesenchymal Umbilical Cord Blood Cells
(J Rheumatol Publ CoTorontoCanadá, 2010)