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In vitro and in vivo activity of benzocphenanthridines against Leishmania amazonensis
(Georg Thieme Verlag, 2014)
Seven benzo[c]phenanthridines, synthetic or isolated from Zanthoxylum rhoifolium root bark, were evaluated against Leishmania amazonensis axenic amastigotes. Five of them were considered leishmanicidal, with IC50 values ...
Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
(Int Union Pure Applied Chemistry, 2012-01-01)
Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, ...
Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
(Int Union Pure Applied Chemistry, 2012-01-01)
Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, ...
Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions
(Royal Society of Chemistry, 2013)
We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (S(N)Ar) reactions of a series of amines towards 1-fluoro-2,4-dinitrobenzene in water. Specific ...
Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions
(Royal Society of Chemistry, 2013)
We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (S(N)Ar) reactions of a series of amines towards 1-fluoro-2,4-dinitrobenzene in water. Specific ...
Conformation and optical activity of copper(II) complexes with L-aminoacids in the visible region
(1976)
The Cotton effect of dd transitions of copper(II) complexes with optically active aminoacids in aqueous media is qualitatively analyzed in terms of conformational models by means of a simple one-electron MO treatment. The ...
Solvent effect on a model SNAr reaction in ionic liquid/water mixtures at different compositions
(Royal Society of Chemistry, 2018)
The reaction of phenyl 2,4,6-trinitrophenyl ether and piperidine was kinetically evaluated in BMIMBF4/water mixtures as the reaction media. This study shows the dramatic effect of the mixture composition on the reacting ...
Explaining secondary school students' attitudes towards chemistry in Chile
(Royal Society of Chemistry, 2020)
Metal-ion effects on the polarization of metal-bound water and infrared vibrational modes of the coordinated metal center of Mycobacterium tuberculosis pyrazinamidase via quantum mechanical calculations
(American Chemical Society, 2014)
Mycobacterium tuberculosis pyrazinamidase (PZAse) is a key enzyme to activate the pro-drug pyrazinamide (PZA). PZAse is a metalloenzyme that coordinates in vitro different divalent metal cofactors in the metal coordination ...