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Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease
(Springer Wien, 2018-08)
The prevalence of Parkinson´s disease, which affects millions of people worldwide, is increasing due to the aging population. In addition to the classic motor symptoms caused by the death of dopaminergic neurons, Parkinson´s ...
The chemically-modified tetracycline COL-3 and its parent compound doxycycline prevent microglial inflammatory responses by reducing glucose-mediated oxidative stress
(MDPI, 2021-08-22)
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial ...
Comparative adsorption of tetracycline onto unmodified and NaOH-modified silicomanganese fumes: kinetic and process modeling
(Institution of Chemical EngineersUnited Kingdom, 2023)
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study
(2019-01-01)
Objective. To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) ...
A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations
(Hindawi Publishing Corporation, 2014-01-01)
Tetracycline-based matrix metalloproteinase-(MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea. The current study addresses the therapeutic potential of a novel pleiotropic ...
Development and application of a highly selective biomimetic sensor for detection of captopril, an important ally in hypertension control
(2010-09-01)
A biomimetic sensor is proposed as a promising new analytical method for determination of captopril in different classes of samples. The sensor was prepared by modifying a carbon paste electrode with iron (II) phthalocyanine ...
Development and application of a highly selective biomimetic sensor for detection of captopril, an important ally in hypertension control
(2010-09-01)
A biomimetic sensor is proposed as a promising new analytical method for determination of captopril in different classes of samples. The sensor was prepared by modifying a carbon paste electrode with iron (II) phthalocyanine ...