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Current state and future perspectives in QSAR models to predict blood-brain barrier penetration in central nervous system drug R&D
(Bentham Science Publishers, 2017-02)
The Blood-Brain Barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability ...
Pharmacology and toxicology of polyphenols with potential as neurotropic agents in non-communicable diseases
(Bentham Science Publishers, 2018-03)
The central nervous system (CNS) is involved in organic integration. Nervousmodulation via bioactive compounds can modify metabolism in order to prevent systemic noncommunicablediseases (NCDs). Concerning this, plant ...
Central Nervous System Targets and Routes for SARS-CoV-2: Current Views and New Hypotheses
(American Chemical Society Inc, 2020-09)
As the coronavirus disease 2019 (COVID-19) pandemic unfolds, neurological signs and symptoms reflect the involvement of targets beyond the primary lung effects. The etiological agent of COVID-19, the severe acute respiratory ...
Involvement of toll-like receptors 3 and 7/8 in the neuropathogenesis of bovine herpesvirus types 1 and 5
(Elsevier, 2016-08)
Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are closely related alpha-herpesviruses. BoHV-5 is the causal agent of non-suppurative meningoencephalitis in calves. BoHV-1 causes respiratory disease, abortions, genital ...
Quinoline analogs of 2-aminoindane as potential central dopaminergic agents
(Birkhauser Boston Inc, 2019-08)
Neurodegenerative disorders such as Parkinson and Huntington Chorea are related with damage to the central dopaminergic system. On the purpose to find new drugs able to re-establish the imbalance on the dopaminergic ...
Applicability of reverse microdialysis in pharmacological and toxicological studies
(Elsevier, 2007-12)
A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher amount of a drug in the perfusate allows the drug to diffuse ...
Role of bovine herpesvirus type 5 (BoHV-5) in diseases of cattle. Recent findings on BoHV-5 association with genital disease
(National Authority for Scientific Research, 2012-05)
Bovine herpesvirus type 5 (BoHV-5) belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. This virus is a major causative agent of non-suppurative meningoencephalitis in young cattle. It ...
Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?
(Freund & Pettman Publishers, 2019-04)
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that involves an intricate interaction between the central nervous system and the immune system. Nevertheless, its etiology is still unknown. MS ...
Bimodal therapeutic agents against Glioblastoma, one of the most lethal forms of cancer
(Wiley VCH Verlag, 2020-08)
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced ...
Memory consolidation and reconsolidation in an invertebrate model: The role of the GABAergic system
(Pergamon-Elsevier Science Ltd, 2009-01)
Consolidation theory assumes that memories are labile during a limited time window after acquisition, but as time passes, memories become stable and resistant to amnesic agents. However, the vision of immutable memories ...