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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Engineering CHO cells galactose metabolism to reduce lactate synthesis
(Springer Netherlands, 2019)
Objective: Over-express galactokinase (Galk1) in tissue plasminogen activator (tPA) producing CHO cells as a potential strategy to improve cell growth and product synthesis. Results: tPA producing CHO cells were transfected ...
Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis
(2013-09-01)
Canine visceral leishmaniosis (CVL) causes a dependent-stage alteration in neutrophil oxidative metabolism. When production of reactive oxygen species (ROS) exceeds the antioxidant capacity of neutrophils, apoptosis is ...
Red LED photobiomodulates the metabolic activity of odontoblast-like cells
(2016-07-01)
Phototherapy has been indicated as an adjunctive treatment for tissue repair, including the pulp tissue. However, there are no defined irradiation parameters, which is a great challenge to the clinical use of phototherapy. ...
Macromolecular biosynthetic parameters and metabolic profile in different life stages of Leishmania braziliensis: Amastigotes as a functionally less active stage
(Public Library of Science, 2017)
It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana ...
The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity
(Cell Press, 2017)
Modulation of gap junction channels and hemichannels by growth factors
(2012)
Gap junction hemichannels and cell–cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination ...