Now showing items 1-10 of 105
Synthesis, characterization and cytotoxicity of Pd(II) complexes for the inhibition of cathepsin B
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-12-13)
Cancer is one of the most dreaded diseases of the 20th century, and its prevalence and incidence are increasing in the 21st century. The situation is so serious that one in four people can develop cancer in their lifetime. ...
Cistatinas de maqui: produção recombinante e inibição de cisteíno peptidases
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2022-02-15)
Cystatins are tight binding competitive inhibitors of cysteine peptidases. In plants, they act regulating different physiological mechanisms, as well as defending from biotic and abiotic stresses, making them of potential ...
Caracterização funcional de uma Cisteíno Catepsina recombinante da formiga cortadeira Atta Sexdens
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2018-04-27)
Cutting ants depend on plant leaves to survive, presenting high damage power in agricultural productions, natural and planted forest. The control of these insects through the use of commercial insecticides besides being ...
Estudo químico-biológico de Dalbergia micolobium Benth (Fabaceae)
(Universidade Federal do Espírito SantoBRMestrado em QuímicaPrograma de Pós-Graduação em QuímicaUFES, 2013-08-29)
This present work describes the chemical study of Dalbergia miscolobium leaves and branches, searching inhibitors of cathepsins K and V. The specie of study is found in Cerrado of state Piaui till state of Parana, possessing ...
Busca de produtos naturais como inibidores específicos de enzimas
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2008-10-24)
The present work describes the search of bioactive secondary metabolites isolated from plants, against enzymes: gGAPDH (glyceraldehydes-3- phosphate dehydrogenase from Trypanosoma cruzi and lysosomal cathepsins K, V, L and ...
Busca de inibidores da catepsina K em plantas medicinais utilizadas no tratamento de doenças osteoarticulares
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-09-26)
Ten herbs used in traditional medicine supported by literature for its effectiveness to osteoarticular diseases were selected to conduct a screening of inhibition activity against the cathepsin K, an important enzyme ...
Biologia molecular aplicada à identificação de alvos para o controle do bicudo da cana-de-açucar, Sphenophorus levis
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2012-02-29)
The sugarcane weevil, Sphenophorus levis, is an insect that feeds on the rhizome of sugarcane in its larval stage, boring channels that cause damage and death to the plant. Conventional methods of insect control have not ...
Sintese e avaliação de peptidomiméticos contendo heterociclos de três membros como inibidores de catepsina L
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2017-12-01)
Cathepsin L is a lysosomal cysteine protease, that is related to many physiological processes, however overexpression and up- or downregulation may cause several pathologies. Therefore, cathepsin L became an interesting ...
Estudo de novas metodologias para realização de ensaios com a catepsina D na busca de inibidores
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2015-02-06)
Cathepsin D is an aspartyl endopeptidase involved in many pathological processes when overexpressed. In addition, it is responsible for degradation of hemoglobin ingested by parasites of schistosomiasis. For these reasons ...
Estudo de produtos naturais e derivados sintéticos buscando inibidores seletivos das catepsinas L e V
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-01-31)
The present work describes the search of bioactive secondary metabolites in plant species of genus Zanthoxylum and synthetic derivatives seeking specific inhibitors of cathepsins L and V. The natural products are involved ...