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cdk5 modulates β- and δ-catenin/Pin1 interactions in neuronal cells
(2007)
The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27
(Springer, 2008-06)
The cadherin-catenin proteins have in common with heat shock proteins (HSP) the capacity to bind/interact proteins of other classes. Moreover, there are common molecular pathways that connect the HSP response and the ...
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Blackwell Publishing Ltd, 2016)
© 2016 International Society for Neurochemistry Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's ...
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Wiley-Blackwell, 2016)
Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's disease. Our previous studies revealed that ...
Modulation of the Notch system in response to Wnt inhibition induces restoration of the rat luteal function
(SAGE Publications, 2020-01)
The aim of this study was to investigate whether the Notch pathway is modulated in response to the downregulation of the Wnt/ Β-catenin system in corpora lutea (CLs) from superovulated rats. To this end, we analyzed the ...
Wnt/β-catenin pathway in the prefrontal cortex is required for cocaine-induced neuroadaptations
(Wiley Blackwell Publishing, Inc, 2017-07)
Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can be divided into two distinct temporal and anatomical domains, ...
Convergence of Wnt and Notch signaling controls ovarian cancer cell survival
(Wiley-liss, Div John Wiley & Sons Inc, 2019-05)
In the last 40 years ovarian cancer mortality rates have slightly declined and,consequently, it continues to be the fifth cause of cancer death in women. In thepresent study, we showed that β‐catenin signaling is involved ...
Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells
(Elsevier B.V., 2019)
© 2018The in vitro process of chondrogenic differentiation of mesenchymal stem cells (MSCs) induces a pre-apoptotic hypertrophic phenotype, guided by the active status of the WNT/β‑catenin pathway. To achieve a stable ...
WNT Signaling Is a Key Player in Alzheimer’s Disease
(Springer Science and Business Media Deutschland GmbH, 2021)
The cellular processes regulated by WNT signaling have been mainly studied during embryonic development and cancer. In the last two decades, the role of WNT in the adult central nervous system has been the focus of interest ...