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The structure of unliganded sterol carrier protein 2 from Yarrowia lipolytica unveils a mechanism for binding site occlusion
(Academic Press Inc Elsevier Science, 2021-03-02)
Isolated or as a part of multidomain proteins, Sterol Carrier Protein 2 (SCP2) exhibits high affinity and broad specificity for different lipidic and hydrophobic compounds. A wealth of structural information on SCP2 domains ...
Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World
(Wiley, 2014)
Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization ...
Binding properties of sterol carrier protein 2 (SCP2) characterized using Laurdan
(Elsevier Science, 2018-11)
Sterol carrier protein 2 (SCP2) binds lipids with high affinity and broad specificity. The overall hydrophobicity, fluidity, and dipolar dynamics of the binding site of SCP2 from Yarrowia lipolytica were characterized using ...
Interaction of S-layer proteins of Lactobacillus kefir with model membranes and cells
(Taylor & Francis, 2017-02)
In previous works, it was shown that S-layer proteins from Lactobacillus kefir were able to recrystallize and stabilize liposomes, this feature reveling a great potential for developing liposomal-based carriers. Despite ...
Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans
(American Physiological Society, 2014)
Solute carrier (SLC) transporters mediate the uptake of biologically active compounds in the intestine. Reduced oxygenation (hypoxia) is an important factor influencing intestinal homeostasis. The aim of this study was to ...
Self-assembled proteins for food applications: A review
(Elsevier Science London, 2020-04-18)
Background: The development of advanced food materials necessarily involves the building of well-known and oriented micro- and nanoarchitectures, which are obtained through the self-assembly of food grade (edible) ...
Surface Plasmon Resonance as a Characterization Tool for Lipids Nanoparticles used in drug delivery
(Frontiers Media, 2021-01)
The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release ...
Matrix Vesicles are carriers of Bone Morphogenetic Proteins (BMPs),
(Springer Tokyo, 2008-12)
Matrix vesicles (MVs) are well-positioned in the growth plate to serve as a carrier of morphogenetic information to nearby chondrocytes and osteoblasts. Bone morphogenetic proteins (BMPs), carried in MVs could promote ...
Rescuing the Rescuer: On the Protein Complex between the Human Mitochondrial Acyl Carrier Protein and ISD11
(American Chemical Society, 2018-06)
Iron-sulfur clusters are essential cofactors in many biochemical processes. ISD11, one of the subunits of the protein complex that carries out the cluster assembly in mitochondria, is necessary for cysteine desulfurase ...