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Brazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments
(2010-08-25)
In 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. ...
Brazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments
(2010-08-25)
In 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. ...
Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays
(Korean Society of Toxicology, 2016-06)
Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be ...
QSAR study for carcinogenicity in a large set of organic compounds
(Bentham Science Publishers, 2012-11)
In our continuing efforts to find out acceptable Absorption, Distribution, Metabolization, Elimination and Toxicity (ADMET) properties of organic compounds, we establish linear QSAR models for the carcinogenic potential ...
Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats
(2018-03-01)
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis ...