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Statin regulation of CYP3A4 and CYP3A5 expression

WILLRICH, Maria Alice Vieira; HIRATA, Mario Hiroyuki; HIRATA, Rosario Dominguez Crespo (FUTURE MEDICINE LTD, 2009)

CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by ...

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican populationRelevancia de la ancestría para la variabilidad de polimorfismos de las enzimas metabolizadoras de fármacos CYP2C9, CYP2C19 y CYP2D6 en una población multiétnica de Costa Rica

Céspedes-Garro, Carolina; Rodrigues-Soares, Fernanda; Jiménez-Arce, Gerardo; G. Naranjo, María-Eugenia; Tarazona-Santos, Eduardo; Fariñas, Humberto; Barrantes, Ramiro; Llerena, Adrián (Universidad de Costa Rica, 2016)

DIFERENCIAS DE LAS FRECUENCIAS DE LOS POLIMORFISMOS DEL CYP3A41B Y CYP3A53,6 Y 7 ENTRE AMERINDIOS HUICHOLES, CORAS Y TARAHUMARAS

Q.F.B. REYES ROSALES, LAURA MARÍA (2011-06-14)

Have been reported many genetic polymorphisms that affect the functionality of the CYP450 enzymes, which are a major cause of adverse effects or therapeutic failure by drugs.CYP3A4 and CYP3A5 are the most important isoforms ...

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population

Coura, Renata dos; Marques, Christiane de Fátima Silva; Koifman, Rosalina J.; Koifman, Sergio; Cabello, Pedro Hernan; Hatagima, Ana (Sociedade Brasileira de Genética, 2018)

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9,CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population

Céspedes-Garro,Carolina; Rodrigues-Soares,Fernanda; Jiménez-Arce,Gerardo; Naranjo,María-Eugenia G.; Tarazona-Santos,Eduardo; Fariñas,Humberto; Barrantes,Ramiro; Llerena,Adrián (Universidad de Costa Rica, 2016)

Avaliação de polimorfismos nos genes CYP1A1, CYP2D6 e CYP19 em uma amostra de pacientes com cancer de mama esporadicoEvaluation of polymorphism in the genes CYP1A1, CYP2D6 and CYP19 in patients with cancer of sporadic breast

Rueda, Lidiane Camila, 1982- ([s.n.], 2008)

Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency

GOMES, Larissa G.; HUANG, Ningwu; AGRAWAL, Vishal; MENDONCA, Berenice B.; BACHEGA, Tania A. S. S.; MILLER, Walter L. (ENDOCRINE SOC, 2009)

Context: 21-Hydroxylase deficiency (21OHD) is caused by CYP21A2 gene mutations disrupting the adrenal 21-hydroxylase, P450c21. CYP21A2 mutations generally correlate well with the 21OHD phenotype, but some children with ...

Cloning a new cytochrome P450 isoform (CYP356A1) from oyster Crassostrea gigas

Silva, Guilherme de Toledo; Siebert, Marília N.; Medeiros, Igor D.; Sincero, Thaís C. M.; Moraes, Milton O.; Goldstone, Jared V.; Bainy, Afonso C. D. (Elsevier, 2019)

Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics

Naranjo, María Eugenia G.; Rodrigues Soares, Fernanda; Peñas Lledó, Eva M.; Tarazona Santos, Eduardo; Fariñas, Humberto; Rodeiro, Idania; Terán, Enrique; Grazina, Manuela; Moya, Graciela E.; López López, Marisol; Sarmiento, Alba P.; Calzadilla, Luis R.; Ramírez Roa, Ronald; Ortiz López, Rocío; Estévez Carrizo, Francisco E.; Sosa Macías, Martha; Barrantes, Ramiro; LLerena, Adrián (Mary Ann Liebert, 2022)

CYP2D6 polymorphism and its clinical implications

Sosa Macias, Martha; Lares Asseff, Ismael (Pharmacological and Toxicological Aspects, 2010, 2010)

Abstract. CYP2D6 is the most important enzyme in the metabolism of drugs and is responsible for the metabolism of 25% of all drugs currently available on the market. CYP2D6 is not only expressed in liver but also in gut ...

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