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Statin regulation of CYP3A4 and CYP3A5 expression
(FUTURE MEDICINE LTD, 2009)
CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by ...
DIFERENCIAS DE LAS FRECUENCIAS DE LOS POLIMORFISMOS DEL CYP3A4*1B Y CYP3A5*3,*6 Y *7 ENTRE AMERINDIOS HUICHOLES, CORAS Y TARAHUMARAS
(2011-06-14)
Have been reported many genetic polymorphisms that affect the functionality of the CYP450 enzymes, which are a major cause of adverse effects or therapeutic failure by drugs.CYP3A4 and CYP3A5 are the most important isoforms ...
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
(Sociedade Brasileira de Genética, 2018)
Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency
(ENDOCRINE SOC, 2009)
Context: 21-Hydroxylase deficiency (21OHD) is caused by CYP21A2 gene mutations disrupting the adrenal 21-hydroxylase, P450c21. CYP21A2 mutations generally correlate well with the 21OHD phenotype, but some children with ...
CYP2D6 polymorphism and its clinical implications
(Pharmacological and Toxicological Aspects, 2010, 2010)
Abstract. CYP2D6 is the most important enzyme in the
metabolism of drugs and is responsible for the metabolism of 25%
of all drugs currently available on the market. CYP2D6 is not only
expressed in liver but also in gut ...