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Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain
(Wiley-Blackwell, 2016-04-01)
The pharmacokinetics of tramadol is characterized by a large interindividual variability, which is partially attributed to polymorphic CYP2D6 metabolism. The contribution of CYP3A, CYP2B6, fraction unbound, and other ...
Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats
(Elsevier B.V., 2015-10-01)
Occupational toxicology and clinical pharmacology integration will be useful to understand potential exposure-drug interaction and to shape risk assessment strategies in order to improve occupational health. The aim of the ...
Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency
(ENDOCRINE SOC, 2009)
Context: 21-Hydroxylase deficiency (21OHD) is caused by CYP21A2 gene mutations disrupting the adrenal 21-hydroxylase, P450c21. CYP21A2 mutations generally correlate well with the 21OHD phenotype, but some children with ...
DIFERENCIAS DE LAS FRECUENCIAS DE LOS POLIMORFISMOS DEL CYP3A4*1B Y CYP3A5*3,*6 Y *7 ENTRE AMERINDIOS HUICHOLES, CORAS Y TARAHUMARAS
(2011-06-14)
Have been reported many genetic polymorphisms that affect the functionality of the CYP450 enzymes, which are a major cause of adverse effects or therapeutic failure by drugs.CYP3A4 and CYP3A5 are the most important isoforms ...
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
(Elsevier, 2001)
CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the
Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val ...
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
(NATURE PUBLISHING GROUPLONDON, 2012)
The impact of biogeographical ancestry, self-reported 'race/color' and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) ...
MODELO MULTIGÉNICO DE IDENTIFICACIÓN DE MUJERES DE ALTO RIESGO A DESARROLLAR CÁNCER DE MAMA POR MEDIO DEL ANÁLISIS POLIMORFICO DE COMPT, CYP17, CYP1A1, CYP19 Y RECEPTOR DE ESTRÓGENO
(2011-04-15)
Background. In Mexico, between women with cancer, the breast cancer is in first
place like the cause of death. 65% of this women belong to the productive group
between 35 to 64 years of age. Furthermore, the number of ...