ABSTRACT Deafness is the most common condition associated with mutations in connexin (Cxs) genes, being mutations in Cx26 gene (GJB2) the most prevalent. Specific mutations in Cx26 also produce syndromic deafness, like ...

Melanoma is the most aggressive skin cancer, and in metastatic advanced states, it is completely refractory to chemotherapy. Therefore, it is relevant to understand the molecular bases that rule their aggressiveness. ...

The aim of this study was to evaluate the expression of connexin (Cx) 37 and Cx43 in canine cumulus-oocyte complexes (COCs) during the oestrous cycle. Cx localisation was analysed by immunohistochemistry and immunofluorescence, ...

Membrane expression of fractalkine (CX 3 CL1)-receptor (CX 3 CR1) is relevant in monocytes (Mo) because CX 3 CR1-CX 3 CL1 interactions might participate on both, homeostatic and pathologic conditions. We have previously ...

Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can ...

Gap junctional intercellular communication (GJIC) and connexin expression (Cx26 and Cx32) in mouse liver were studied after administration of 4-bis[2-(3,5 dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme ...

Linoleic acid (LA) is known to activate G-protein coupled receptors and connexin hemichannels (Cx HCs) but possible interlinks between these two responses remain unexplored. Here, we evaluated the mechanism of action of ...

Mutations in human connexin (Cx) genes have been related to diseases, which we termed connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness (Cx26, Cx30), Charcot Marie Tooth disease (Cx32), ...