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Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities
(Elsevier Masson, 2015-07)
In this work, a series of hybrid compounds were tested as antiparasitic substances. These hybrids were prepared from bile acids and a series of antiparasitic Cinchona alkaloids by the formation of a covalent C–C bond via ...
Antiparasitic hybrids of Cinchona alkaloids and bile acids
(Elsevier Masson, 2013-08)
A series of 16 hybrids of Cinchona alkaloids and bile acids (4a–h, 5a–h) was prepared by means of a Barton–Zard decarboxylation reaction. Quinine, quinidine, cinchonine and cinchonidine were functionalized at position C-2 ...
Enantioseparation of -amino acids by means of Cinchona alkaloids asselectors in chiral ligand-exchange chromatography
(Elsevier Science, 2013-07)
A conventional nonchiral column was used for the enantioseparation of several racemic -amino acids (native and derivatized) through the use of Cinchona alkaloids as chiral selectors along with Cu(II) ions in chiral ...
Chiral ligand-exchange chromatography with Cinchona alkaloids. Exploring experimental conditions for enantioseparation of α-amino acids
(Elsevier Science, 2016-11)
The natural Cinchona alkaloid quinidine as chiral selector in chiral ligand-exchange chromatography was systematically studied. Chromatographic conditions for enantioseparation of twentya-amino acidswere first timestudied ...
Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents against Trypanosoma cruzi
(Molecular Diversity Preservation International, 2019-08)
The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus ...
Reaction of singlet molecular oxygen, O2(1 Δg), with the Cinchona tree alkaloids: Effect of absolute configuration on the total rate constant
(2005)
Detection of O2(1Δg) emission, λmax = 1270 nm, following laser excitation and steady-state methods were employed to measure the total reaction rate constant, kT, and the reactive reaction rate constant, kR, for the reaction ...
Perfiles cromatográficos y cuantificación de alcaloides totales y quinina de dos especies de Cinchona procedentes de la región Cajamarca
(Universidad Nacional de TrujilloPE, 2022)
El presente informe tuvo como objetivo comparar los perfiles cromatográficos y cuantificar alcaloides totales y quinina de extractos de dos especies de Cinchona procedentes de la región Cajamarca. Las plantas de Cinchona ...