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How does early maternal separation and chronic stress in adult rats affect the immunoreactivity of serotonergic neurons within the dorsal raphe nucleus?
(Taylor & Francis Ltd, 2018-01)
Vulnerability to emotional disorders like depression derives from interactions between early and late environments, including stressful conditions. The serotonin (5HT) system is strongly affected by stress and chronic ...
Homocysteine levels, oxidative status and hemostatic response to chronic stress in rats
(Trade Science Inc, 2015-08)
Several studies have shown that homocysteine (Hcy) levels are affected by diet factors and non-diet factors such as stress. Increases in total Hcy plasma concentrations are recognized as an independent risk factor for ...
Long-term impact of chronic variable stress in adolescence versus adulthood
(Pergamon-Elsevier Science Ltd, 2019-01)
Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result ...
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma
(Elsevier, 2020-06)
Purpose: Chronic and persistent exposure to negative stress can lead to adverse consequences on health. Particularly, psychosocial factors were found to increase the risk and outcome of respiratory diseases like asthma. ...
Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
(Pergamon-Elsevier Science Ltd, 2012-02)
Brain substance P and its receptor (neurokinin-1, NK1) have a widespread brain distribution and are involved in an important number of behavioural and physiological responses to emotional stimuli. However, the role of NK1 ...
Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology?
(Pergamon-Elsevier Science Ltd, 2016-02)
A growing body of evidence has demonstrated that astrocytes play a pivotal role in the normal functioning of the nervous system. This new conceptual framework has set the groundwork to be able to hypothesize that astrocytes ...
Involvement of nitric oxide in improving stress-induced behavioural alteration by glatiramer acetate treatment in female BALB/c mice
(Springer Verlag Berlín, 2015-05)
Rationale: Oxidative stress and neurotrophins are among the most important factors involved in several pathophysiological brain processes. In addition, long-term exposure to stressful situations has deleterious effects on ...
Maternal separation in early life modifies anxious behavior and Fos and glucocorticoid receptor expression in limbic neurons after chronic stress in rats: Effects of tianeptine.
(Taylor & Francis Ltd, 2016-01)
Early-life adversity can lead to long-term consequence persisting into adulthood. Here, we assess the implications of an adverse early environment on vulnerability to stress during adulthood. We hypothesized that the ...
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation
(Taylor & Francis Ltd, 2009-12)
The aim of this work was to determine the effect of chronic treatment with 5 mg/Kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, ...
Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
(Taylor & Francis, 2009-12)
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test ...